On Coliva’s Judgmental Hinges

Judgmental Sampling

Opening the pore hinges on proline.

absence of Hh ligand, Ptc restrains Smo activity ; binding of Hh to Ptc releases Smo, which then transmits the intracellular signal. The regulation of Smo activity therefore occupies a pivotal position in the cellular response to Hh. Previous work had identified small molecules that inhibit or activate Hh signaling by interacting with Smo 6–8. These include the antagonist cyclopamine as well as...

Flexible antibodies with nonprotein hinges

There is a significant need for antibodies that can bind targets with greater affinity. Here we describe a novel strategy employing chemical semisynthesis to produce symmetroadhesins: antibody-like molecules having nonprotein hinge regions that are more flexible and extendible and are capable of two-handed binding. Native chemical ligation was carried out under mild, non-denaturing conditions t...

Elastica with Hinges

Tape-Spring Rolling Hinges

This paper presents a new design of a low cost, unlubricated, self-deploying, self-locking hinge whose properties can be easily modified to meet different requirements. A particular implementation is considered, providing a hinge that is 135 mm long, 30 mm high and 45 mm wide, with a deployment moment varying between 0.1 and 0.3 Nm and a locking moment of 13 Nm. Stiffness tests have been carrie...